Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-affinity aptamers to subtype 3a hepatitis C virus polymerase display genotypic specificity.

Antimicrobial agents and chemotherapy - 1 Sept 2006

Jones Louisa A, Clancy Leighton E, Rawlinson William D, White Peter A

Abstract excerpt

Research into antiviral agents directed at hepatitis C virus (HCV) proteins is commonly based and tested on a single genotype, namely, genotype 1. This is despite the high level of variability of the RNA virus and the frequency of infection with genotypes other than genotype 1. The systematic evolution of ligands by exponential enrichment (SELEX) is a novel in vitro approach used in this study that allows rapid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aptamers, Nucleotide
Share to Hepacivirus
Share to Kinetics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Structure

Share to Nucleic Acid Conformation

Share to RNA-Dependent RNA Polymerase

Share to Sequence Alignment

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 16940097
DOI: 10.1128/AAC.01603-05
PMCID: PMC1563542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-affinity aptamers to subtype 3a hepatitis C virus polymerase display genotypic specificity.PMID 16940097Read ↗

In vitro Selection of High Affinity DNA and RNA Aptamers that Detect Hepatitis C Virus Core Protein of Genotypes 1 to 4 and Inhibit Virus Production in Cell Culture.Semantic proximity Read ↗

RNA-dependent RNA polymerases from different hepatitis C virus genotypes reveal distinct biochemical properties and drug susceptibilities.Semantic proximity Read ↗

Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.Semantic proximity Read ↗

Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase.Semantic proximity Read ↗

In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons.Semantic proximity Read ↗

Over-expression and characterization of NS3 and NS5A of Hepatitis C virus genotype 3a.Semantic proximity Read ↗

Inhibition of Hepatitis C Virus Production by Aptamers against the Core ProteinSemantic proximity Read ↗

Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir.Semantic proximity Read ↗

High antiviral activity of NS5A inhibitor ABT-530 with paritaprevir/ritonavir and ribavirin against hepatitis C virus genotype 3 infection.Semantic proximity Read ↗

The hepatitis C virus NS5A protein and response to interferon alpha: mutational analyses in patients with chronic HCV genotype 3a infection from India.Semantic proximity Read ↗

Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro.Semantic proximity Read ↗

Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.