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Article

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase.

Nucleic acids research - 1 Dec 2008

Li Na, Wang Yuxuan, Pothukuchy Arti, Syrett Angel, Husain Naeem, Gopalakrisha Siddharth, Kosaraju Pradeepa, Ellington Andrew D

Abstract excerpt

Drug-resistant variants of HIV-1 reverse transcriptase (RT) are also known to be resistant to anti-RT RNA aptamers. In order to be able to develop diagnostics and therapies that can focus on otherwise drug-resistant viruses, we have isolated two aptamers against a well-known, drug-resistant HIV-1 RT, Mutant 3 (M3) from the multidrug-resistant HIV-1 RT panel. One aptamer, M302, bound M3 but showed no significant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Viral

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Source

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Identifiers

PMID: 18948292
DOI: 10.1093/nar/gkn775
PMCID: PMC2588506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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