Article
Vitamin D receptor and aromatase gene interaction and bone mass in older African-American women.
Metabolism: clinical and experimental - 1 May 2003
Zmuda Joseph M, Cauley Jane A, Danielson Michelle E, Ferrell Robert E
Abstract excerpt
Aromatization of androgens by the CYP19 gene product, aromatase, is the major source of endogenous estrogen in postmenopausal women. We determined whether an Arg(264)Cys polymorphism in the CYP19 gene is associated with bone mineral density (BMD) and bone loss in older women. Because vitamin D regulates CYP19 gene expression, we also tested for an interaction with a translation start site polymorphism in the...
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