Article
Significant association between common polymorphisms in the aromatase gene CYP19A1 and bone mineral density in postmenopausal women.
Calcified tissue international - 1 Dec 2011
Mullin B H, Carter K W, Lewis J R, Ingley E, Wilson S G, Prince R L
Abstract excerpt
17β-Estradiol is important in maintaining bone structure, and regulation of its synthesis plays an important role in the development of postmenopausal osteoporosis. We and others have demonstrated associations between variation in the CYP19A1 gene (encoding aromatase) and areal bone mineral density (aBMD) phenotypes in women. In the present study 33 tag polymorphisms were genotyped across the CYP19A1 gene in a...
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