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Article

Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast.

The Journal of biological chemistry - 7 Sept 2001

Blaiseau P L, Lesuisse E, Camadro J M

Abstract excerpt

The yeast, Saccharomyces cerevisiae, contains a transcription activator, Aft1p, that regulates the transcription of the high affinity iron transport system genes. This report describes the properties of Aft2p, a protein 39% homologous to Aft1p. Aft2p was found to activate transcription. Overproduction of Aft2p activates the transcription of the AFT1 target gene FET3. The double aft1aft2 mutant was unable to grow...

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Identifiers

PMID: 11448968
DOI: 10.1074/jbc.M104987200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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