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Article

Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli.

Journal of bacteriology - 1 Jun 2003

Rock Charles O, Park Hee-Won, Jackowski Suzanne

Abstract excerpt

Pantothenate kinase (CoaA) is a key regulator of coenzyme A (CoA) biosynthesis in Escherichia coli, and its activity is controlled by feedback inhibition by CoA and its thioesters. The importance of feedback inhibition in the control of the intracellular CoA levels was tested by constructing three site-directed mutants of CoaA that were predicted to be feedback resistant based on the crystal structure of the...

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Identifiers

PMID: 12754240
DOI: 10.1128/JB.185.11.3410-3415.2003
PMCID: PMC155388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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