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Article

Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants.

Applied and environmental microbiology - 1 Nov 2005

Lütke-Eversloh Tina, Stephanopoulos Gregory

Abstract excerpt

In order to get insights into the feedback regulation by tyrosine of the Escherichia coli chorismate mutase/prephenate dehydrogenase (CM/PDH), which is encoded by the tyrA gene, feedback-inhibition-resistant (fbr) mutants were generated by error-prone PCR. The tyrA(fbr) mutants were selected by virtue of their resistance toward m-fluoro-D,L-tyrosine, and seven representatives were characterized on the biochemical...

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Identifiers

PMID: 16269762
DOI: 10.1128/AEM.71.11.7224-7228.2005
PMCID: PMC1287721

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Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants.PMID 16269762Read ↗

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