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Article

The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.

The Journal of biological chemistry - 14 Oct 2005

Thomas Jacob, Cronan John E

Abstract excerpt

The acyl carrier proteins (ACPs) of fatty acid synthesis are functional only when modified by attachment of the prosthetic group, 4'-phosphopantetheine (4'-PP), which is transferred from CoA to the hydroxyl group of a specific serine residue. Almost 40 years ago Vagelos and Larrabee reported an enzyme from Escherichia coli that removed the prosthetic group. We report that this enzyme, called ACP hydrolyase or ACP...

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PMID: 16107329
DOI: 10.1074/jbc.M505736200

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