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Article

Crystal structure of ketopantoate reductase from Thermococcus kodakarensis complexed with NADP(.).

Acta crystallographica. Section F, Structural biology communications - 1 May 2016

Aikawa Yoshiki, Nishitani Yuichi, Tomita Hiroya, Atomi Haruyuki, Miki Kunio

Abstract excerpt

Coenzyme A (CoA) plays pivotal roles in a variety of metabolic pathways in all organisms. The biosynthetic pathway of CoA is strictly regulated by feedback inhibition. In the hyperthermophilic archaeon Thermococcus kodakarensis, ketopantoate reductase (KPR), which catalyzes the NAD(P)H-dependent reduction of 2-oxopantoate, is a target of feedback inhibition by CoA. The crystal structure of KPR from T....

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Identifiers

PMID: 27139828
DOI: 10.1107/S2053230X16005033
PMCID: PMC4854564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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