Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel mutations in the pheA gene of Escherichia coli K-12 which result in highly feedback inhibition-resistant variants of chorismate mutase/prephenate dehydratase.

Applied and environmental microbiology - 1 Aug 1992

Nelms J, Edwards R M, Warwick J, Fotheringham I

Abstract excerpt

The bifunctional enzyme chorismate mutase/prephenate dehydratase (EC 5.4.99.5/4.2.1.51), which is encoded by the pheA gene of Escherichia coli K-12, is subject to strong feedback inhibition by L-phenylalanine. Inhibition of the prephenate dehydratase activity is almost complete at concentrations of L-phenylalanine greater than 1 mM. The pheA gene was cloned, and the promoter region was modified to enable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to Escherichia coli

Share to Genes, Bacterial

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 1514806
DOI: 10.1128/aem.58.8.2592-2598.1992
PMCID: PMC195826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel mutations in the pheA gene of Escherichia coli K-12 which result in highly feedback inhibition-resistant variants of chorismate mutase/prephenate dehydratase.PMID 1514806Read ↗

Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants.Semantic proximity Read ↗

Probing the catalytic mechanism of prephenate dehydratase by site-directed mutagenesis of the Escherichia coli P-protein dehydratase domain.Semantic proximity Read ↗

Yeast allosteric chorismate mutase is locked in the activated state by a single amino acid substitution.Semantic proximity Read ↗

Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method.Semantic proximity Read ↗

Mutation that affects pepN translation initiation in Escherichia coli.Semantic proximity Read ↗

Introduction of two mutations into AroG increases phenylalanine production in Escherichia coli.Semantic proximity Read ↗

Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli.Semantic proximity Read ↗

Patterns of activation of the norleucine activity of a quadruple mutant derived from clostridial glutamate dehydrogenase.Semantic proximity Read ↗

Regulation of chorismate mutase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Escherichia coli cis- and trans-acting mutations that increase glyA gene expression.Semantic proximity Read ↗

Analysis of the mutant proBA operon from a proline-producing strain of Serratia marcescens.Semantic proximity Read ↗

Evidence that there are only two tRNA(Phe) genes in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.