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Article

Kinetics and regulation of pantothenate kinase from Escherichia coli.

The Journal of biological chemistry - 28 Oct 1994

Song W J, Jackowski S

Abstract excerpt

Pantothenate kinase catalyzes the rate-controlling step in coenzyme A (CoA) biosynthesis and is regulated by feedback inhibition by CoA. Pantothenate kinase was purified to homogeneity from Escherichia coli and was shown to exist as a homodimer. Kinetic analysis indicated the presence of two ATP binding sites that exhibited positive cooperativity with a Hill coefficient of 1.46. Site-directed mutagenesis of...

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PMID: 7929447

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