Article
Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Hartmann Markus, Schneider Thomas R, Pfeil Andrea, Heinrich Gabriele, Lipscomb William N, Braus Gerhard H
Abstract excerpt
The betaalpha barrel is the common protein fold of numerous enzymes and was proposed recently to be the result of gene duplication and fusion of an ancient half-barrel. The initial enzyme of shikimate biosynthesis possesses the additional feature of feedback regulation. The crystal structure and kinetic studies on chimera and mutant proteins of yeast 3-deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthase...
Topics
- 3-Deoxy-7-Phosphoheptulonate Synthase
- Alleles
- Amino Acid Sequence
- Amino Acids
- Crystallography, X-Ray
- Enzymes
- Glycine
- Kinetics
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Isoforms
- Protein Structure, Tertiary