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Article

Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003

Hartmann Markus, Schneider Thomas R, Pfeil Andrea, Heinrich Gabriele, Lipscomb William N, Braus Gerhard H

Abstract excerpt

The betaalpha barrel is the common protein fold of numerous enzymes and was proposed recently to be the result of gene duplication and fusion of an ancient half-barrel. The initial enzyme of shikimate biosynthesis possesses the additional feature of feedback regulation. The crystal structure and kinetic studies on chimera and mutant proteins of yeast 3-deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthase...

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Identifiers

PMID: 12540830
DOI: 10.1073/pnas.0337566100
PMCID: PMC298692

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