Article
Influence of mutation in the regulatory domain of α-isopropylmalate synthase from Saccharomyces cerevisiae on its activity and feedback inhibition.
Bioscience, biotechnology, and biochemistry - 24 May 2022
Takagi Hironobu, Yamamoto Kazuki, Matsuo Yoshifumi, Furuie Miki, Kasayuki Yasuha, Ohtani Rina, Shiotani Mizuki, Hasegawa Tetsuya, Ohnishi Toru, Ohashi Masataka, Johzuka Katsuki, Kurata Atsushi, Uegaki Koichi
Abstract excerpt
Isoamyl alcohol (i-AmOH) is produced from α-ketoisocaproate in the l-leucine biosynthetic pathway in yeast and controlled by the negative feedback regulation of α-isopropylmalate synthase (IPMS), which senses the accumulation of l-leucine. It is known that i-AmOH production increases when mutations in the regulatory domain reduce the susceptibility to feedback inhibition. However, the impact of mutations in this...
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