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Article

Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.

The Journal of biological chemistry - 17 Jul 2009

Aberg Espen, Torgersen Knut Martin, Johansen Bjarne, Keyse Stephen M, Perander Maria, Seternes Ole-Morten

Abstract excerpt

ERK3 and ERK4 are atypical MAPKs in which the canonical TXY motif within the activation loop of the classical MAPKs is replaced by SEG. Both ERK3 and ERK4 bind, translocate, and activate the MAPK-activated protein kinase (MK) 5. The classical MAPKs ERK1/2 and p38 interact with downstream MKs (RSK1-3 and MK2-3, respectively) through conserved clusters of acidic amino acids, which constitute the common docking (CD)...

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Identifiers

PMID: 19473979
DOI: 10.1074/jbc.M109.023283
PMCID: PMC2740564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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