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Article

Short interfering RNA‐directed inhibition of hepatitis B virus replication

24 Apr 2003

Abstract excerpt

RNA interference (RNAi) is the process by which double-stranded RNA directs sequence-specific degradation of mRNA. In mammalian cells, RNAi can be triggered by 21-nucleotide duplexes of short interfering RNA (siRNA). We examined effects of siRNA on hepatitis B virus (HBV) replication. Human hepatoma cells were transfected with HBV DNA and siRNA against HBV-pregenome RNA. Transfection experiments demonstrated that...

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PMID: 12753904
DOI: 10.1016/s0014-5793(03)00400-9

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