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Investigational RNA Interference Agents for Hepatitis B

7 Dec 2024

Abstract excerpt

Functional cure of chronic hepatitis B (CHB)-defined as sustained seroclearance of hepatitis B surface antigen (HBsAg) with unquantifiable hepatitis B virus (HBV) DNA at 24 weeks off treatment, is an optimal treatment endpoint. Nonetheless, it cannot be consistently attained by current treatment modalities. RNA interference (RNAi) is a novel treatment strategy using small-interfering RNA (siRNA) or antisense...

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PMID: 39644435
DOI: 10.1007/s40259-024-00694-x

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