Article
The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes.
Pigment cell research - 1 Jun 2003
Sturm Richard A, Duffy David L, Box Neil F, Chen Wei, Smit Darren J, Brown Darren L, Stow Jennifer L, Leonard J Helen, Martin Nicholas G
Abstract excerpt
We have examined melanocortin-1 receptor (MC1R) variant allele frequencies in the general population and in a collection of adolescent dizygotic and monozygotic twins to determine statistical associations of pigmentation phenotypes with increased skin cancer risk. This included hair and skin color, freckling, mole count and sun exposed skin reflectance. Nine variants were studied and designated as either strong R...
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