Article
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2011
Saetre Peter, Vares Maria, Werge Thomas, Andreassen Ole A, Arinami Tadao, Ishiguro Hiroki, Nanko Shinichiro, Tan Ene Choo, Han Doug Hyun, Roffman Joshua L, Muntjewerff Jan-Willem, Jagodzinski Pawel P, Kempisty Bartosz, Hauser Joanna, Vilella Elisabet, Betcheva Elitza, Nakamura Yusuke, Regland Björn, Agartz Ingrid, Hall Håkan, Terenius Lars, Jönsson Erik G
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is involved in the one-carbon cycle, which is of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes two common polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) which both alter enzyme activity. The T-allele of the C677T polymorphism has recently been associated with earlier age at onset of...
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