Article
Dopa decarboxylase genotypes may influence age at onset of schizophrenia.
Molecular psychiatry - 1 Nov 2001
Børglum A D, Hampson M, Kjeldsen T E, Muir W, Murray V, Ewald H, Mors O, Blackwood D, Kruse T A
Abstract excerpt
Several lines of evidence implicate dopa decarboxylase (DDC) with schizophrenia. By analysis of two putative functional DDC variants in 173 schizophrenic patients and 204 controls we tested the hypotheses that DDC is involved in: (1) predisposition to schizophrenia; and (2) modulation of age at disease onset. No association was observed with schizophrenia as a whole, whereas an association between DDC genotypes...
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