Article
Relationship between cardiac protein tyrosine phosphorylation and myofibrillogenesis during axolotl heart development.
Tissue & cell - 1 Apr 2003
Meng F, Huang X P, Zhang C, Zajdel R W, Foster D, Dawson N, Lemanski S L, Zawieja D, Dube D K, Lemanski L F
Abstract excerpt
The axolotl, Ambystoma mexicanum, is a useful system for studying embryogenesis and cardiogenesis. To understand the role of protein tyrosine phosphorylation during heart development in normal and cardiac mutant axolotl embryonic hearts, we have investigated the state of protein tyrosine residues (phosphotyrosine, P-Tyr) and the relationship between P-Tyr and the development of organized sarcomeric myofibrils by...
Topics
- Ambystoma mexicanum
- Animals
- Blotting, Western
- Electrophoresis, Polyacrylamide Gel
- Embryo, Nonmammalian
- Heart
- Isoelectric Focusing
- Microscopy, Confocal
- Mutation
- Organ Culture Techniques