Article
Creation of chimeric mutant axolotls: a model to study early embryonic heart development in Mexican axolotls.
Anatomy and embryology - 1 May 2001
Lemanski L F, Meng F, Lemanski S L, Dawson N, Zhang C, Foster D, Li Q, Nakatsugawa M, Zajdel R W, Dube D K, Huang X
Abstract excerpt
The Mexican axolotl (Ambystoma mexicanum) provides an excellent model for studying heart development since it carries a cardiac lethal mutation in gene c that results in failure of contraction of mutant embryonic myocardium. In cardiac mutant axolotls (c/c) the hearts do not beat, apparently because of an absence of organized myofibrils. To date, there has been no way to analyze the genotypes of embryos from...
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