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Article

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene.

Biochemical and biophysical research communications - 30 May 2003

Imai Hirotaka, Hirao Fumi, Sakamoto Taro, Sekine Kanae, Mizukura Yumi, Saito Makoto, Kitamoto Takeo, Hayasaka Michiko, Hanaoka Kazunori, Nakagawa Yasuhito

Abstract excerpt

Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is the only known intracellular antioxidant enzyme that can directly reduce lipid hydroperoxide in membrane. Mitochondrial and non-mitochondrial PHGPx and sperm nuclei GPx are transcribed from one gene by alternative transcription using different first exons Ia and Ib, respectively. To examine the role of PHGPx in development, we generated mice deficient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12745070
DOI: 10.1016/s0006-291x(03)00734-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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