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Article

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

26 Sept 2009

Abstract excerpt

Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the mitochondria of testis and spermatozoa. We previously found a significant decrease in the expression of GPx4 in spermatozoa from 30% of infertile human males diagnosed with oligoasthenozoospermia (Imai, H., Suzuki, K., Ishizaka, K.,...

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PMID: 19783653
DOI: 10.1074/jbc.m109.016139

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