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Article

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.

Molecular and cellular biology - 1 Aug 2006

Ferretti Elisabetta, Villaescusa J Carlos, Di Rosa Patrizia, Fernandez-Diaz Luis C, Longobardi Elena, Mazzieri Roberta, Miccio Annarita, Micali Nicola, Selleri Licia, Ferrari Giuliana, Blasi Francesco

Abstract excerpt

The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity, nuclear localization, and likely, function in development. To understand the in vivo role of Prep1, we have analyzed an embryonic lethal hypomorphic mutant mouse (Prep1(i/i)). Prep1(i/i) embryos die at embryonic day 17.5 (E17.5) to birth with an overall organ hypoplasia, severe anemia, impaired angiogenesis, and eye...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16847320
DOI: 10.1128/MCB.00313-06
PMCID: PMC1592771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.PMID 16847320Read ↗

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