Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

5 May 2009

Abstract excerpt

ABSTRACT Selenium is linked to male fertility. Glutathione peroxidase 4 (GPx4), first described as an antioxidant enzyme, is the predominant selenoenzyme in testis and has been suspected of being vital for spermatogenesis. Cytosolic, mitochondrial, and nuclear isoforms are all encoded by the same gene. While disruption of entire GPx4 causes early embryonic lethality in mice, inactivation of nuclear GPx4 does not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Reproductive System and Pregnancy
Share to Selenium in Biological Systems
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19417079
DOI: 10.1096/fj.09-132795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial glutathione peroxidase 4 disruption causes male infertilityPMID 19417079Read ↗

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in MiceSemantic proximity Read ↗

Selenium in mammalian spermiogenesisSemantic proximity Read ↗

Male Fertility Is Linked to the Selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase1Semantic proximity Read ↗

Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.Semantic proximity Read ↗

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present EvidencesSemantic proximity Read ↗

Mitochondrial Functionality in Male Fertility: From Spermatogenesis to FertilizationSemantic proximity Read ↗

Genetic variations of gpx-4 and male infertility in humans.Semantic proximity Read ↗

Peroxiredoxin 6: The Protector of Male FertilitySemantic proximity Read ↗

Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity 1Semantic proximity Read ↗

<i>Prm2</i> deficiency triggers a Reactive Oxygen Species (ROS)-mediated destruction cascade during epididymal sperm maturation in miceSemantic proximity Read ↗

Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice.Semantic proximity Read ↗

GPX4: old lessons, new featuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.