Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase.

Nucleic acids research - 1 Aug 2003

Ufer Christoph, Borchert Astrid, Kuhn Hartmut

Abstract excerpt

Phospholipid hydroperoxide glutathione peroxidase (phGPx) is a member of the seleno glutathione peroxidase family that is comprised of five selenoproteins capable of reducing hydroperoxy lipids to the corresponding alcohols. The enzyme has been implicated in antioxidative defense, but its high ex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Flanking Region
Share to CCAAT-Binding Factor
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Peroxidase

Share to Regulatory Sequences, Nucleic Acid

Share to Sp1 Transcription Factor

Share to Transcription Initiation Site

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 12888488
DOI: 10.1093/nar/gkg650
PMCID: PMC169948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12888488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase.PMID 12888488Read ↗

Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidase.Semantic proximity Read ↗

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene.Semantic proximity Read ↗

Selenium in mammalian spermiogenesisSemantic proximity Read ↗

Genetic variations of gpx-4 and male infertility in humans.Semantic proximity Read ↗

Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis.Semantic proximity Read ↗

Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization.Semantic proximity Read ↗

Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4).Semantic proximity Read ↗

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.Semantic proximity Read ↗

Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activationSemantic proximity Read ↗

Promoter characterization of the human and mouse epilysin (MMP-28) genes.Semantic proximity Read ↗

Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.Semantic proximity Read ↗

Role of transcription factor Sp1 and CpG methylation on the regulation of the human podocalyxin gene promoterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.