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Article

Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.

The Biochemical journal - 1 Apr 2009

Iuchi Yoshihito, Okada Futoshi, Tsunoda Satoshi, Kibe Noriko, Shirasawa Nobuyuki, Ikawa Masahito, Okabe Masaru, Ikeda Yoshitaka, Fujii Junichi

Abstract excerpt

Prx (peroxiredoxin) is a multifunctional redox protein with thioredoxin-dependent peroxidase activity. Prx4 is present as a secretory protein in most tissues, whereas in sexually mature testes it is anchored in the ER (endoplasmic reticulum) membrane of spermatogenic cells via an uncleaved N-terminal hydrophobic peptide. We generated a Prx4 knockout mouse to investigate the function of Prx4 in vivo. Prx4(-/y)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19105792
DOI: 10.1042/BJ20081526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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