Article

A <i>Trypanosoma brucei gambiense</i> gene variant confers human serum resistance

2026-06-16

Abstract excerpt

Most species of African trypanosomes cannot infect humans due to the presence in our blood of trypanolytic factors (TLFs). These lipoprotein particles contain the apolipoprotein L1 (ApoLI) toxin which, when internalised by trypanosomes, forms pores and causes cell death. However, two subspecies of Trypanosoma brucei have evolved resistance to TLFs and cause Human African Trypanosomiasis (HAT). The mechanism of re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea945869-2516-5e34-bd3b-6c158cf49fbf
DOI: 10.64898/2026.06.16.732631

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A <i>Trypanosoma brucei gambiense</i> gene variant confers human serum resistanceDOI 10.64898/2026.06.16.732631Read

Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum ResistanceSemantic proximity Read

Mechanism of <i>Trypanosoma brucei gambiense</i> (group 1) resistance to human trypanosome lytic factorSemantic proximity Read

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection.Semantic proximity Read

The TgsGP Gene Is Essential for Resistance to Human Serum in Trypanosoma brucei gambienseSemantic proximity Read

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genomeSemantic proximity Read

Differences between Trypanosoma brucei gambiense Groups 1 and 2 in Their Resistance to Killing by Trypanolytic Factor 1Semantic proximity Read

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei bruceiSemantic proximity Read

The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa1Semantic proximity Read

Endosomal Localization of the Serum Resistance-Associated Protein in African Trypanosomes Confers Human InfectivitySemantic proximity Read

GENETIC DIVERSITY OF <i>T. B. RHODESIENSE</i> SERUM RESISTANCE ASSOCIATED GENE IN MALAWIAN ISOLATESSemantic proximity Read

C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.Semantic proximity Read

Biological and demographic causes of high HIV and sexually transmitted disease prevalence in men who have sex with menSemantic proximity Read