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Article

Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8.

Molecular biology of the cell - 1 Mar 2003

Lillico Simon, Field Mark C, Blundell Pat, Coombs Graham H, Mottram Jeremy C

Abstract excerpt

The survival of Trypanosoma brucei, the causative agent of Sleeping Sickness and Nagana, is facilitated by the expression of a dense surface coat of glycosylphosphatidylinositol (GPI)-anchored proteins in both its mammalian and tsetse fly hosts. We have characterized T. brucei GPI8, the gene encoding the catalytic subunit of the GPI:protein transamidase complex that adds preformed GPI anchors onto nascent...

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Source

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Identifiers

PMID: 12631733
DOI: 10.1091/mbc.e02-03-0167
PMCID: PMC151589

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8.PMID 12631733Read ↗

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