Article
Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19.
Annals of the rheumatic diseases - 1 May 2007
Livshits Gregory, Kato Bernet S, Zhai Guangju, Hart Deborah J, Hunter David, MacGregor Alex J, Williams Frances M K, Spector Tim D
Abstract excerpt
BACKGROUND AND OBJECTIVE: Until recently, there has been little agreement between conflicting results of osteoarthritis (OA) linkage. The purpose of this study was to conduct a whole-genome linkage scan to identify susceptibility loci for idiopathic hand OA in a large, population-based sample of females. METHODS: Two OA-related radiographic phenotypes DIP (distal interphalangeal joints)-OA and Tot-KL...
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