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Article

Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma.

Clinical pharmacology and therapeutics - 1 May 2003

Obase Yasushi, Shimoda Terufumi, Kawano Tetsuya, Saeki Sachiko, Tomari Shin-Ya, Mitsuta-Izaki Kazuko, Matsuse Hiroto, Kinoshita Moritoshi, Kohno Shigeru

Abstract excerpt

BACKGROUND: Cytochrome p450 (CYP) 1A2 gene polymorphisms are thought to be involved in theophylline metabolism. OBJECTIVE: We analyzed the effect of genetic polymorphisms in the 5'-flanking region to the first intron of the CYP1A2 gene on theophylline metabolism in 75 Japanese patients with asthma and 159 healthy Japanese volunteers. METHODS: Genetic polymorphisms were detected at 4 sites of the CYP1A2 gene,...

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Identifiers

PMID: 12732846
DOI: 10.1016/s0009-9236(03)00013-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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