Article
Possible association of SLC22A2 polymorphisms with aspirin-intolerant asthma.
International archives of allergy and immunology - 1 Jan 2011
Park Tae-Joon, Kim Jeong-Hyun, Bae Joon-Seol, Park Byung-Lae, Cheong Hyun Sub, Chun Ji-Yong, Lee Jin-Sol, Kim Jason Yongha, Pasaje Charisse Flerida, Cho Sang Heon, Uh Soo-Taek, Kim Mi-Kyeong, Choi Inseon S, Koh In Song, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
BACKGROUND: Aspirin-intolerant asthma (AIA) is a clinical syndrome characterized by acute bronchoconstriction following the ingestion of aspirin. Solute carrier family 22, member 2 (SLC22A2), also known as organic cation transporter 2 (OCT2), is predominantly expressed in the luminal membrane of airway epithelial cells and has been shown to mediate the transport of prostaglandins on the cyclooxygenase pathway...
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