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Article

Estimation of the interindividual variability of cytochrome 2D6 activity from urinary metabolic ratios in the literature.

Drug metabolism and pharmacokinetics - 1 Jan 2010

Ito Takashi, Kato Motohiro, Chiba Koji, Okazaki Osamu, Sugiyama Yuichi

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is an enzyme with a large interindividual variability in its metabolic activity due to genetic polymorphisms. In the present study, both its intrinsic metabolic activity (CL(int,CYP2D6,app)) relative to extensive metabolizers (EM) and its variability were estimated by...

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PMID: 20610883
DOI: 10.2133/dmpk.25.243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20610883-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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