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Article

Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor alpha.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2004

Villablanca Amparo, Lubahn Dennis, Shelby Lauren, Lloyd Kent, Barthold Stephen

Abstract excerpt

OBJECTIVE: Vascular tissues express 2 types of estrogen receptors (ERs): ERalpha and ERbeta. Their role in early atherosclerosis remains poorly understood, particularly in males. We developed and characterized an atherosclerosis model in ERalpha knockout male mice to investigate directly its role in atheroma. METHODS AND RESULTS: Cholesterol-fed ERalpha knockout and wild-type mice developed early atheroma...

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Source

Identifiers

PMID: 15117737
DOI: 10.1161/01.ATV.0000130467.65290.d4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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