Article
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.
The Journal of clinical investigation - 15 Jun 1998
Rajavashisth T, Qiao J H, Tripathi S, Tripathi J, Mishra N, Hua M, Wang X P, Loussararian A, Clinton S, Libby P, Lusis A
Abstract excerpt
Previous studies of osteopetrotic (op) mice lacking macrophage colony-stimulating factor (M-CSF) have revealed an inhibition of atherosclerosis development in the apolipoprotein E (apo E)-deficient model and in a diet-induced model. Using LDL receptor-deficient mice, we now show that atheroma dev...
Topics
- Animals
- Arteriosclerosis
- Cell Differentiation
- Heterozygote
- Homozygote
- Macrophage Colony-Stimulating Factor
- Macrophages
- Mice
- Monocytes
- Mutation
- Osteopetrosis
- Receptors, LDL