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Article

Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.

The Journal of clinical investigation - 15 Jun 1998

Rajavashisth T, Qiao J H, Tripathi S, Tripathi J, Mishra N, Hua M, Wang X P, Loussararian A, Clinton S, Libby P, Lusis A

Abstract excerpt

Previous studies of osteopetrotic (op) mice lacking macrophage colony-stimulating factor (M-CSF) have revealed an inhibition of atherosclerosis development in the apolipoprotein E (apo E)-deficient model and in a diet-induced model. Using LDL receptor-deficient mice, we now show that atheroma development depends on M-CSF concentration, as not only did homozygous osteopetrotic (op/op) mice have dramatically...

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Identifiers

PMID: 9637704
DOI: 10.1172/JCI119891
PMCID: PMC508861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.PMID 9637704Read ↗

Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E.Semantic proximity Read ↗

Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?Semantic proximity Read ↗

Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.Semantic proximity Read ↗

Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages.Semantic proximity Read ↗

Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.Semantic proximity Read ↗

Reduced macrophage-dependent inflammation improves endothelin-1-induced vascular injury.Semantic proximity Read ↗

The biology and action of colony stimulating factor-1.Semantic proximity Read ↗

Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice.Semantic proximity Read ↗

Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification.Semantic proximity Read ↗

Colony stimulating factor 1 (CSF-1) and its in vivo role as delineated using osteopetrotic op/op mice.Semantic proximity Read ↗

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner.Semantic proximity Read ↗

Follicular development and ovulation in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation.Semantic proximity Read ↗

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