Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A humanized osteopontin mouse model and its application in immunometabolic obesity studies.

Translational research : the journal of laboratory and clinical medicine - 1 Dec 2016

Grün Nicole G, Zeyda Karina, Moreno-Viedma Veronica, Strohmeier Karin, Staffler Günther, Zeyda Maximilian, Stulnig Thomas M

Abstract excerpt

Osteopontin (OPN) is a multifunctional protein involved in several inflammatory processes and pathogeneses including obesity-related disorders and cancer. OPN binds to a variety of integrin receptors and CD44 resulting in a proinflammatory stimulus. Therefore, OPN constitutes a novel interesting target to develop new therapeutic strategies, which counteract OPN's proinflammatory properties. We established a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Glucose

Share to Diet, High-Fat

Share to Homologous Recombination

Share to Hypertrophy

Share to Insulin Resistance

Share to Osteopontin

Source

Identifiers

PMID: 27490454
DOI: 10.1016/j.trsl.2016.07.009

Genes

SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A humanized osteopontin mouse model and its application in immunometabolic obesity studies.PMID 27490454Read ↗

Osteopontin: Its Properties, Recent Studies, and Potential ApplicationsSemantic proximity Read ↗

SPP1 macrophages across diseases: A call for reclassification?Semantic proximity Read ↗

The critical role of osteopontin (OPN) in fibrotic diseasesSemantic proximity Read ↗

[Osteopontin, a multi-faceted molecule].Semantic proximity Read ↗

The Intracellular and Secreted Sides of Osteopontin and Their Putative Physiopathological RolesSemantic proximity Read ↗

Decoding SPP1 regulation: Genetic and nongenetic insights into its role in disease progressionSemantic proximity Read ↗

Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammationSemantic proximity Read ↗

Human osteopontin: Potential clinical applications in cancer (Review)Semantic proximity Read ↗

Role of osteopontin in the pathophysiology of cancerSemantic proximity Read ↗

Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases.Semantic proximity Read ↗

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age.Semantic proximity Read ↗

In Vivo Overexpression of Tissue-Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of OsteopontinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.