Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between angiotensin-converting enzyme and catechol-O-methyltransferase genotypes in schizophrenics with poor response to conventional neuroleptics.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 May 2003

Illi Ari, Kampman Olli, Anttila Sami, Roivas Markus, Mattila Kari M, Lehtimäki Terho, Leinonen Esa

Abstract excerpt

Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine. Functional polymorphism in the COMT and ACE genes causes variation in enzyme activities. We investigated the relationship of COMT and ACE gene polymorphism with response to conventional neuroleptic treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Logistic Models

Share to Peptidyl-Dipeptidase A

Share to Psychiatric Status Rating Scales

Share to Schizophrenia

Share to Treatment Failure

Source

Identifiers

PMID: 12729939
DOI: 10.1016/s0924-977x(02)00176-1

Genes

ACE
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between angiotensin-converting enzyme and catechol-O-methyltransferase genotypes in schizophrenics with poor response to conventional neuroleptics.PMID 12729939Read ↗

Catechol-O-methyltransferase and monoamine oxidase A genotypes and drug response to conventional neuroleptics in schizophrenia.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) pharmacogenetics in the treatment response phenotypes of major depressive disorder (MDD).Semantic proximity Read ↗

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity.Semantic proximity Read ↗

Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment.Semantic proximity Read ↗

Interaction between NOTCH4 and catechol-O-methyltransferase genotypes in schizophrenia patients with poor response to typical neuroleptics.Semantic proximity Read ↗

Association between a COMT polymorphism and clinical response to risperidone treatment: a pharmacogenetic study.Semantic proximity Read ↗

Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia.Semantic proximity Read ↗

Impact of catechol-o-methyltransferase polymorphisms on risperidone treatment for schizophrenia and its potential clinical significance.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population.Semantic proximity Read ↗

Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment.Semantic proximity Read ↗

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.Semantic proximity Read ↗

Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.