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Article

Selection on human genes as revealed by comparisons to chimpanzee cDNA.

Genome research - 1 May 2003

Hellmann Ines, Zollner Sebastian, Enard Wolfgang, Ebersberger Ingo, Nickel Birgit, Paabo Svante

Abstract excerpt

To better understand the evolutionary forces that affect human genes, we sequenced 5055 expressed sequence tags from the chimpanzee and compared them to their human counterparts. In conjunction with intergenic chimpanzee DNA sequences and data on human single-nucleotide polymorphisms in the genes studied, this allows us to gauge the extent to which selection affects human genes at a genome-wide scale. The...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12727903
DOI: 10.1101/gr.944903
PMCID: PMC430916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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