Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in mRNA coding sequences of highly conserved genes.

Physiological genomics - 2 Apr 2001

Ten Asbroek A L, Olsen J, Housman D, Baas F, Stanton V

Abstract excerpt

The frequency and distribution of genetic polymorphism in the human genome is a question of major importance. We have studied this in highly conserved genes, which encode crucial functions such as DNA replication, mRNA transcription, and translation. Evolutionary comparisons suggest that these genes are under particularly strong selective pressure, and their frequency of nucleotide sequence polymorphism would be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Conserved Sequence
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to RNA, Messenger

Share to Sequence Homology, Amino Acid

Share to Yeasts

Source

Identifiers

PMID: 11285364
DOI: 10.1152/physiolgenomics.2001.5.3.113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in mRNA coding sequences of highly conserved genes.PMID 11285364Read ↗

Analysis of human mRNAs with the reference genome sequence reveals potential errors, polymorphisms, and RNA editing.Semantic proximity Read ↗

Conserved non-genic sequences - an unexpected feature of mammalian genomes.Semantic proximity Read ↗

Individual variation in protein-coding sequences of human genome.Semantic proximity Read ↗

DNA variability of human genes.Semantic proximity Read ↗

Efficient discovery of single-nucleotide polymorphisms in coding regions of human genes.Semantic proximity Read ↗

The patterns of natural variation in human genes.Semantic proximity Read ↗

Evolutionary conservation in noncoding genomic regions.Semantic proximity Read ↗

Genome-wide analysis of single-nucleotide polymorphisms in human expressed sequencesSemantic proximity Read ↗

Characterization of single-nucleotide polymorphisms in coding regions of human genes.Semantic proximity Read ↗

Localization and characterization of mouse-human alignments within the human genome. Does evolutionary conservation suggest functional importance?Semantic proximity Read ↗

Human genome sequences: enigmatic variations.Semantic proximity Read ↗

Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.