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Article

Hotspots of biased nucleotide substitutions in human genes.

PLoS biology - 27 Jan 2009

Berglund Jonas, Pollard Katherine S, Webster Matthew T

Abstract excerpt

Genes that have experienced accelerated evolutionary rates on the human lineage during recent evolution are candidates for involvement in human-specific adaptations. To determine the forces that cause increased evolutionary rates in certain genes, we analyzed alignments of 10,238 human genes to their orthologues in chimpanzee and macaque. Using a likelihood ratio test, we identified protein-coding sequences with...

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Identifiers

PMID: 19175294
DOI: 10.1371/journal.pbio.1000026
PMCID: PMC2631073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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