Article
Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data.
Genome biology and evolution - 2 Jul 2016
Kainov Yaroslav A, Aushev Vasily N, Naumenko Sergey A, Tchevkina Elena M, Bazykin Georgii A
Abstract excerpt
Polyadenylation is a step of mRNA processing which is crucial for its expression and stability. The major polyadenylation signal (PAS) represents a nucleotide hexamer that adheres to the AATAAA consensus sequence. Over a half of human genes have multiple cleavage and polyadenylation sites, resulting in a great diversity of transcripts differing in function, stability, and translational activity. Here, we use...
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