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Article

Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch.

Cancer research - 1 May 2003

Fedorov Lev M, Papadopoulos Thomas, Tyrsin Oleg Y, Twardzik Thomas, Götz Rudolf, Rapp Ulf R

Abstract excerpt

One of the most frequent malignancies in humans is lung adenocarcinoma.To develop novel diagnostic and therapeutic approaches for the management of this disease, animal models are required. We have used transgenic mice with lung-targeted expression of the CRaf kinase to evaluate genes altered frequently in human lung adenocarcinoma for their effect on tumor progression. Here we report that loss of p53...

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PMID: 12727849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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