Article
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
Genes & development - 15 Dec 2001
Fisher G H, Wellen S L, Klimstra D, Lenczowski J M, Tichelaar J W, Lizak M J, Whitsett J A, Koretsky A, Varmus H E
Abstract excerpt
To investigate the role of an activated K-Ras gene in the initiation and maintenance of lung adenocarcinomas, we developed transgenic mice that express murine K-Ras4b(G12D) under the control of doxycycline in type II pneumocytes. Focal proliferative lesions of alveolar type II pneumocytes were observed as early as seven days after induction with doxycycline; after two months of induction, the lungs contained...
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