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Article

Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf.

Cancer research - 1 Nov 2002

Fedorov Lev M, Tyrsin Oleg Yu, Papadopoulos Thomas, Camarero Guadalupe, Götz Rudolf, Rapp Ulf R

Abstract excerpt

The efficiency of tumor induction by oncogenes is influenced by modifier genes that determine individual susceptibility. We have used a transgenic mouse model to examine the role of a candidate susceptibility gene, bcl-2, for development of Raf oncogene-induced lung adenomas. Loss of bcl-2 greatly retarded tumor development without affecting tumor phenotype. Tumor tissues from bcl-2 positive and negative mice...

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PMID: 12414660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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