Article
Genotype-phenotype relationships in a mouse model for human small-cell lung cancer.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2005
Calbó J, Meuwissen R, van Montfort E, van Tellingen O, Berns A
Abstract excerpt
Lung tumors are usually classified into small-cell lung cancer (SCLC) or non-SCLC (NSCLC) depending on their pathological and histological characteristics. SCLC is defined not only by its characteristic neuroendocrine differentiation, aggressiveness, and metastatic potential, but also by a specific set of genetic aberrations, including the loss of the tumor suppressor genes p53 and Rb1 and the amplification of...
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