Article

Mechanistic insight into sex differences in lung cancer induced by cRaf

2023-03-01

Abstract excerpt

Women are at greater risk of developing lung cancer (LC); yet the underlying causes are unknown. To gain insight into sex difference in LC, we investigated tumor growth in a cRaf transgenic disease model. Overexpression of the cRaf kinase induced an extraordinary 8-fold increase in tumor growth among females, and nearly 70% of the 112 differentially expressed genes (DEGs) were female specific. We identified oncoge...

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Literature Corpus work: a4042438-bf3e-5d2a-8a21-c033b93f168a
DOI: 10.21203/rs.3.rs-2599586/v1

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