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TP53 loss‐of‐function causes vulnerability to autophagy inhibition in aggressive prostate cancer

17 Aug 2022

Abstract excerpt

OBJECTIVES: TP53 loss-of-function is commonly found in aggressive prostate cancer. However, a highly-efficient therapy for this tumor subtype is still lacking. In this study, we investigated the relationship between TP53 mutation status and autophagy in prostate cancer and assessed the efficacy of autophagy inhibitors on TP53-deficient tumors. METHODS: We first evaluated the expression patterns of p53 and...

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PMID: 35975690
DOI: 10.1111/iju.15021

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