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Article

Expression of Androgen Receptor Is Negatively Regulated By p53

1 Dec 2007

Abstract excerpt

Increased expression of androgen receptor (AR) in prostate cancer (PC) is associated with transition to androgen independence. Because the progression of PC to advanced stages is often associated with the loss of p53 function, we tested whether the p53 could regulate the expression of AR gene. Here we report that p53 negatively regulates the expression of AR in prostate epithelial cells (PrECs). We found that in...

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PMID: 18084622
DOI: 10.1593/neo.07769

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