Article
Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.
Cancer research - 1 May 2003
Krop Ian, Maguire Paula, Lahti-Domenici Jaana, Lodeiro Gabriela, Richardson Andrea, Johannsdottir Hrefna Kristin, Nevanlinna Heli, Borg Ake, Gelman Rebecca, Barkardottir Rosa Björk, Lindblom Annika, Polyak Kornelia
Abstract excerpt
We recently identified a candidate tumor suppressor gene, HIN-1, that is silenced due to methylation in the majority of sporadic breast carcinomas and is localized to 5q33-qter, an area frequently lost in BRCA1 tumors and thought to harbor a BRCA1 modifier gene. To establish whether germ-line mutations in HIN-1 may influence breast cancer risk, we sequenced the HIN-1 coding region in 10 familial breast cancer...
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