Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypomutable regions of yeast TFIIB in a unigenic evolution test represent structural domains.

Gene - 24 Apr 2003

Zeng Xiao, Zhang Dongyi, Dorsey Michael, Ma Jun

Abstract excerpt

As genome sequences of many organisms - including humans - are being decoded, there is a great need for genetic tools to analyze newly discovered genes/proteins. A 'unigenic evolution' approach has been previously proposed for dissecting protein domains, which is based on the assumption that functionally important regions of a protein may tolerate missense mutations less well than other regions. We describe a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli
Share to Evolution, Molecular
Share to Glutathione Transferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Recombinant Fusion Proteins

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae Proteins

Share to Transcription Factor TFIIB

Source

Identifiers

PMID: 12727357
DOI: 10.1016/s0378-1119(03)00492-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypomutable regions of yeast TFIIB in a unigenic evolution test represent structural domains.PMID 12727357Read ↗

Development of an unbiased statistical method for the analysis of unigenic evolution.Semantic proximity Read ↗

Identification of cis-suppression of human disease mutations by comparative genomics.Semantic proximity Read ↗

Frequent gain and loss of functional transcription factor binding sites.Semantic proximity Read ↗

A nonconserved surface of the TFIIB zinc ribbon domain plays a direct role in RNA polymerase II recruitment.Semantic proximity Read ↗

Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.Semantic proximity Read ↗

Identity and divergence of protein domain architectures after the yeast whole-genome duplication event.Semantic proximity Read ↗

Random field model reveals structure of the protein recombinational landscape.Semantic proximity Read ↗

Interaction of the TFIIB zinc ribbon with RNA polymerase II.Semantic proximity Read ↗

Identification of functional transcription factor binding sites using closely related Saccharomyces species.Semantic proximity Read ↗

A single helix repression domain is functional across eukaryotesSemantic proximity Read ↗

Evolutionary dynamics on protein bi-stability landscapes can potentially resolve adaptive conflicts.Semantic proximity Read ↗

Arrangements in the modular evolution of proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.